Long-term decline of renal function in patients with resistant and non-resistant arterial hypertension

Abstract Background The negative effect of arterial hypertension on renal function is well known. Until present, the detrimental resistant (RAH) kidneys was not clearly defined. Purpose To assess deterioration in patients with RAH comparison to non-resistant (AH) during a long term follow-up. Methods We retrospectively reviewed records 307 followed between May 2007 and January 2019 an Hypertension Excellence Centre tertiary hospital. In all we assessed basic demographic characteristics, co-morbidities, laboratory findings, secondary causes AH, medication, blood pressure including ambulatory monitoring, studies invasive procedures (CT, MRI, coronarography). statistically evaluated differences both groups compared decline function. Results 160 had 147 hypertension. Patients were for mean 6 years. older (58.1±10.8 years vs. 51±13 years), more frequently diabetics (39.3% 8.7%), frequent exposure diagnostic (86,5% 64%). Age at baseline visit diabetes mellitus established as significant independent risk factors. Linear mixed model adjusted age demonstrated that have increased than AH: AH increase creatinine +0.24 μmol/l per year, while + 2.12 year (P=0.005). Similarly decrease eGFR −0.66 −1.5 mL/s/1.73 m2 Figures 1 2 show difference slope (based linear models)). Conclusion faster independently diabetes. Further are needed determine key factors affecting subgroups. Funding Acknowledgement Type funding sources: Public grant(s) – National budget only. Main source(s): University Hospital Olomouc, Palacky Faculty Medicine, Czech Republic